16 02, 2023

#AGBT23: what was hot in the hottest NGS tech conference?

By | February 16th, 2023|Categories: Uncategorized|Tags: |0 Comments

I recently returned from the AGBT meeting in Sunny Florida (where it was hot) just 8 months after last years COVID delayed event. That event saw the launch of multiple new Sequencing Companies: Element Bio, Singular Genomics, and Ultima Genomics (the $100 genome company). And […]

20 11, 2019

@illumina response to CMA

By | November 20th, 2019|Categories: Uncategorized|6 Comments

Illumina’s response to the CMA’s recent findings that their acquisition of PacBio would be anti-competitive was published on the CMA website today. And both theirs, and PacBio’s stock are up (a little bit) as a result. Their suggested remedies include: To grant a perpetual, royalty-free, […]

8 10, 2019

@Illumina and @Qiagen’s IVD deal: what does it mean for NGS?

By | October 8th, 2019|Categories: Next-generation sequencing, Uncategorized|1 Comment

Yesterday Illumina and Qiagen announced a 15 year deal to partner on development of NGS in vitro diagnostic kits to run on Illumina sequencers. And Qiagen, more quietly, announced that development of the GeneReader platform will cease. The second piece of news is unsurprising; I’d written about Qiagens […]

25 07, 2019

Will @Illumina succeed in buying @PacBio?

By | July 25th, 2019|Categories: Uncategorized|8 Comments

The current CMA report “Anticipated acquisition by Illumina, Inc. of Pacific Biosciences of California, Inc. Decision on relevant merger situation and substantial lessening of competition” makes for some interesting, if frustrating, reading. Interesting because of what the report says but frustrating because of the redaction […]

19 06, 2019

@Illumina moving into baseball?

By | June 19th, 2019|Categories: Uncategorized|1 Comment

OK so Illumina is not (to my knowledge) planing on sponsoring the San Diego Padres. The title of this post was inspired by a wonderful bit of mistaken transcription of the recent Goldman Sachs Healthcare conference presentation by Francis deSouza “sequencers today generate baseball”…I think […]

18 04, 2019

#CRISPR Diagnostics part 2

By | April 18th, 2019|Categories: Diagnostics Tech, Methods and applications, Uncategorized|Tags: , |0 Comments

#CRISPR diagnostics got even more exciting with two big announcements last month. Firstly, Sherlock Biosciences, has spun out from The Broad Institute and Wyss Institute commercialising the SHERLOCK and INSPECTR technologies (I’ll be covering the battle for CRISPR Dx dominance in this post). Secondly, researchers at […]

21 09, 2018

Cell line variability – what will you do?

By | September 21st, 2018|Categories: Uncategorized|0 Comments

Last month Nature published a paper that revealed what many scientists knew or suspected. Cancer cell lines evolve very quickly due to positive clonal selection driven by cell culture conditions. And that this is likely the reason why the same cell line used in different labs […]

15 06, 2018

Illumina’s revenue in perspective

By | June 15th, 2018|Categories: Uncategorized|2 Comments

An interesting round up of the Top 10 Sequencing Companies from Genetic Engineering & Biotechnology News highlights the dominance of Illumina on the life-sciences (genomics) industry. Illumina’s $2.752 billion in 2017 is almost double the combined revenue of the other 9 companies ($1.445 billion). With giants […]

15 05, 2018

Ex vivo perfusion for donor organs: a BBC Tomorrow’s World special

By | May 15th, 2018|Categories: I am not a clinician, Other stuff, Uncategorized, Videos|0 Comments

Last night I watched in amazement as a beating heart was brought into the UK for transplant surgery – the heart was kept alive in the OCS HEART system. The BBC program Heart Transplant: A Chance to Live is outstanding TV and if you can […]

5 01, 2018

Cut&Run-Seq – an alternative to ChIP?

By | January 5th, 2018|Categories: Uncategorized|2 Comments

There’s a great paper from Pete Skene, postdoc 2011-2017 in the Henikoff lab, on eLife: An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites. The paper describes a novel method that performs as well as ChIP-Seq, but with lower background and false-positives. ChIP-seq is […]

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