18 04, 2019

#CRISPR Diagnostics part 2

By | April 18th, 2019|Categories: Diagnostics Tech, Methods and applications, Uncategorized|Tags: , |0 Comments

#CRISPR diagnostics got even more exciting with two big announcements last month. Firstly, Sherlock Biosciences, has spun out from The Broad Institute and Wyss Institute commercialising the SHERLOCK and INSPECTR technologies (I’ll be covering the battle for CRISPR Dx dominance in this post). Secondly, researchers at […]

8 03, 2019

Applying sWGS for copy-number analysis in FFPE tumour tissue

By | March 8th, 2019|Categories: Library Prep, Methods and applications, Next-generation sequencing|0 Comments

Cancer is a disease driven by mutation and copy-number aberration (CNA) yet most of the data generated to date has focused on SNV and InDel calling – the easy part of DNA analysis, particularly in ctDNA. This means that not enough focus has been put […]

28 02, 2019

Sesquizygosity due to heterogonesis confirmed by @10Xgenomics linked-reads

By | February 28th, 2019|Categories: 10X Genomics, I am not a clinician, Next-generation sequencing|0 Comments

A case report in the New England Journal of Medicine describes a pair of sesquizygotic twins, they share an identical maternal allele, but are chimeric (to different degrees) for two separately identical paternal alleles. The initial ultrasound at 6-weeks showed monozygotic twins, but at 14 weeks it was […]

12 12, 2018

@10XGenomics now does #spatialomics

By | December 12th, 2018|Categories: 10X Genomics, Methods and applications, Next-generation sequencing, Single-cell sequencing|0 Comments

10Xgenomics buys Spatial Transcriptomics: Single-cell methods are having at least as big an impact on our understanding of biology as microarrays did when they first appeared in the mid-to-late 1990s. And now that 10X Genomics have bought Spatial Transcriptomics many single-cell users are likely to […]

18 10, 2018

Single-cell cancer sequencing on BioRxiv

By | October 18th, 2018|Categories: 10X Genomics, Methods and applications, Next-generation sequencing, Single-cell sequencing|0 Comments

Three recent papers from Sam Apraicio (@sajraparicio) and Sorab Shah (@SohrabShah) are well worth a read on BioRxiv. In June Kieran Cambell posted a paper describing computational methods to integrate single-cell DNA and RNA-Seq data. And in September Camila de Souza and Emma Laks posted reports […]

16 10, 2018

The dangers of Outlook autocomplete

By | October 16th, 2018|Categories: Other stuff|1 Comment

We’ve all done it. You get a reply from someone saying they don’t think the message was meant for them, and it was simply because Microsoft Outlook autocomplete put the last James you emailed in the address instead of the James you actually meant to […]

21 09, 2018

Cell line variability – what will you do?

By | September 21st, 2018|Categories: Uncategorized|0 Comments

Last month Nature published a paper that revealed what many scientists knew or suspected. Cancer cell lines evolve very quickly due to positive clonal selection driven by cell culture conditions. And that this is likely the reason why the same cell line used in different labs […]

14 08, 2018

@InnovateUK – Women in Innovation award

By | August 14th, 2018|Categories: Other stuff|0 Comments

Innovate UK is running a competition for Women in Innovation. The £50,000 grant from Innovate Uk can be used for mentoring, coaching and business support. Projects must be linked to the Industrial Strategy Grand Challenges. Read about the 2016 winners and learn how the Innovate UK […]

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