A case report in the New England Journal of Medicine describes a pair of sesquizygotic twins, they share an identical maternal allele, but are chimeric (to different degrees) for two separately identical paternal alleles. The initial ultrasound at 6-weeks showed monozygotic twins, but at 14 weeks it was […]
I’m a little late getting this list of books that I think will make great Christmas presents published here, but you can always pick them up in the January sales! All five are available from WHSmith – the most ethical of the UK’s highstreet bookshops […]
10Xgenomics buys Spatial Transcriptomics: Single-cell methods are having at least as big an impact on our understanding of biology as microarrays did when they first appeared in the mid-to-late 1990s. And now that 10X Genomics have bought Spatial Transcriptomics many single-cell users are likely to […]
Consider the title of this post. Illumina just spent two times more on PacBio in 2018 than they did on Solexa in 2006. $1.2 billion on a technology that many would say is under huge pressure from @ONT, and is a company burning cash fast…very […]
Three recent papers from Sam Apraicio (@sajraparicio) and Sorab Shah (@SohrabShah) are well worth a read on BioRxiv. In June Kieran Cambell posted a paper describing computational methods to integrate single-cell DNA and RNA-Seq data. And in September Camila de Souza and Emma Laks posted reports […]
We’ve all done it. You get a reply from someone saying they don’t think the message was meant for them, and it was simply because Microsoft Outlook autocomplete put the last James you emailed in the address instead of the James you actually meant to […]
Last month Nature published a paper that revealed what many scientists knew or suspected. Cancer cell lines evolve very quickly due to positive clonal selection driven by cell culture conditions. And that this is likely the reason why the same cell line used in different labs […]
Innovate UK is running a competition for Women in Innovation. The £50,000 grant from Innovate Uk can be used for mentoring, coaching and business support. Projects must be linked to the Industrial Strategy Grand Challenges. Read about the 2016 winners and learn how the Innovate UK […]
Genomes, exomes, panels. Patients, doctors and the general public are hearing about things that simply didn’t exist 10 years ago. IO therapy is big news but TMB, a likely biomarker for immunotherapy response, is a simple concept often poorly explained. It is clear that a […]
GenomeWeb carry coverage of the work by Battelle Memorial Institute, Harvard University, Virginia Tech, and Ginkgo Bioworks who are all developing methods to detect sequences that could “be put to nefarious use”. This suggests a couple of things to me. First and foremost are these companies […]
