Andrew Adey’s group at OHSU published sci-MET – a single cell method for whole-genome methylation analysis in Nature Biotech last month: Highly scalable generation of DNA methylation profiles in single cells. In this they described their indexing method and report on an analysis of over 3000 […]
“It’s not the size that matters, it’s what you do with it that counts!” Turns out that the first statement very much does matter when it comes to cell free DNA. It is becoming clearer that the size of cfDNA and ctDNA is information that […]
Last night I watched in amazement as a beating heart was brought into the UK for transplant surgery – the heart was kept alive in the OCS HEART system. The BBC program Heart Transplant: A Chance to Live is outstanding TV and if you can […]
On Friday last week I had the pleasure of hosting a half-day Nanostring symposium at Cancer Research UK’s Cambridge Institute (my previous employer). The symposium was arranged as an opportunity to get Nanostring users, and potential users, together to hear about the exciting developments in […]
The FDA issued a safety communication today on the risk that biotin supplements “can significantly interfere with certain lab tests and cause incorrect test results”. The FDA communiqué mentions an increase in reported adverse events, and even one death, because of Biotin interference. Biotin interferes with some […]
For readers of this blog who don’t remember The X-files the reference may be lost on you, but the work published in Genome Research today will not. In Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia Gary Nolan’s group at Stanford report on […]
Last week the first issue of a new journal debuted: The CRISPR Journal. With a massive number of journals out there why should any of us care about a new one? I would not normally read the first issue of a Journal (although I did […]
Two papers in Science last week show how CRISPR can be used as a diagnostic tool. The first comes from the same team at The Broad that brought us the SHERLOCK method, the second from Jennifer Dounda’s group at Berkley. Both methods promise simple diagnostics […]
The 10XGenomics workshop just closed at AGBT and they announced some truly revolutionary new applications: single-cell feature barcoding, single-cell ATAC-Seq and single-cell CNV (feat CBGB). I’ll go through each of these in more detail below but I wanted to start by highlighting the success of single-cell analysis […]
Can transplant genomics help better understand ctDNA? Circulating cell free (cfDNA) of tumour (ctDNA) is released by apoptotic and necrotic cells into blood and other bodily fluids. It has transformed NIPT and is transforming Cancer medicine. However the biology behind it’s release is still not […]
