21 10, 2016

Does the world have too many HiSeq X Tens?

By | October 21st, 2016|Categories: Next-generation sequencing|6 Comments

Illumina stock dropped 25% after a hammering by the stock market with their recent announcements that Q3 revenues would be 3.4% lower than expected at just $607 million. This makes Illumina a much more attractive acquisition (although I doubt this summers rumours of a Thermo […]

17 10, 2016

SIRVs: RNA-seq controls from @Lexogen

By | October 17th, 2016|Categories: Commissioned content, Next-generation sequencing, Single-cell sequencing|1 Comment

This article was commissioned by Lexogen GmbH. My lab has been performing RNA-seq for many years, and is currently building new services around single-cell RNA-seq. Fluidigm’s C1, academic efforts such as Drop-seq and inDrop, and commercial platforms from 10X Genomics, Dolomite Bio, Wafergen, Illumina/BioRad, RainDance and others makes establishing […]

14 10, 2016

Batch effects in scRNA-seq: to E or not to E(RCC spike-in)

By | October 14th, 2016|Categories: "Experimental design controls etc"|0 Comments

At the recent Wellcome Trust conference on Single Cell Genomics (Twitter #scgen16) there was a great talk (her slides are online) from Stephanie Hicks in the @irrizarry group (Department of Biostatistics and Computational Biology at Dana-Farber Cancer Institute). Stephanie was talking about the recent work she’s […]

11 10, 2016

Clinical trials using ctDNA

By | October 11th, 2016|Categories: Uncategorized|0 Comments

DeciBio have a great interactive Tableau dashboard which you can use to browse and filter their analysis of 97 “laboratory biomarker analysis†ImmunOncolgy clinical trials; see: Diagnostic Biomarkers for Cancer Immunotherapy – Moving Beyond PD-L1. The raw data comes from ClinicalTrials.gov where you can specify […]

16 09, 2016

Reporting on Fluidigm’s single-cell user meeting at the Sanger Institute

By | September 16th, 2016|Categories: Conferences, Next-generation sequencing, Single-cell sequencing|0 Comments

The Genomics community is pushing ahead fast on single-cell analysis methods as these are revolutionising how we approach biological questions. Unfortunately my registration went in too late for the meeting running at the Sanger Institute this week (Follow #SCG16 on Twitter), but the Fluidigm pre-meeting was a […]

14 09, 2016

10X Genomics publications

By | September 14th, 2016|Categories: 10X Genomics, Next-generation sequencing|0 Comments

Anyone that’s been reading Core-Genomics will have seen my interest in the technology from 10X Genomics. I’ve been watching and waiting for publications to come out to get a better understanding of how people are using the technology and thought you might like my current […]

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