In 2013 researchers from Oxford’s Molecular Diagnostics Centre, NIHR BRC, WTCHG and Department of Oncology led by Anna Schuh and Jenny Taylor sequenced 351 lung, melanoma and colorectal tumours from patients using an NGS 46-gene hotspot cancer panel. Results were delivered with a median turnaround of 7 days […]
Clive Brown presented a webinar on Tuesday with multiple updates on Oxford Nanopore technology, Keith Robison covered them all over at OmicsOmics, but I’ll just be focussing on the launch of GridION X5. If you want to know more about GridION, PromethION, Throughput, 1D^2 Chemistry, Basecalling, the FPGA Basecalling Accelerator, and a […]
Two publications presenting really cool technologies recently caught my attention: “Lego for molecular biology” and “CATCH-Seq: CRISPR for target enrichment sequencing”. Both are technologies I’d like to play with, and my son can join in the Lego modelling if we build some here in Cambridge! Lego […]
A paper published one month ago in Nature Genetics: Stessman et al 2017, by Evan Eichler’s group at HHMI, reported finding 91 genes associated with neuro-developmental disorders. 25 of these were enriched in autism probands and the authors reported a “network associated with high-functioning autism (full-scale IQ >100)”. […]
The Oxford Nanopore MinION is generating some truly staggering read-lengths. Keith Robison has summarised many of the major advances of the past few months; MinKNOW increasing yield by reducing pore blockage with a “nano-Heimlich manoeuvre” which increases yields to 10Gb (ONT’s CSO Clive Brown has self […]
For me one of the top talks at #AGBT17 was in a concurrent session. Theodore Davis from New England Biolabs presented “APOBEC-Seq: An enzymatic method for methylome analysis at single-base resolution without bisulfite treatment.” His talk focused on some of the cons of using sodium bisulfite sequencing for methylation in epigenetic […]
Illumina have finally dropped the NeoPrep from their lineup after a short but pretty rocky road. Launched at AGBT15 the instrument promised hassle free library prep automation for users that did not require full 96well plate production-scale solutions. Early access users I spoke to at […]
Cambridge Epigenetix (@CEGX_news) have a list of almost 50 papers on their website using their technology for DNA methylation and hydroxymethylation analysis, which I thought readers of CoreGenomics might be interested in. They also have a list of Epigenetics Conferences coming up….enjoy! The papers: Chen et […]
This years #AGBT17 did not look as exciting as previous years have done, especially with all the major announcements being made at JP Morgan. In fact Illumina even went as far as to say they’d have no news at all during the conference! However there was […]
Nanostring had an interesting poster presented by Joe Beecham at last years AGBT describing their novel single-molecule hybridization-based sequencing chemistry (see AGBT and JPMorgan 2016 coverage from GenomeWeb). This utilizes the Nanostring optical barcodes in a new configuration to deliver Hyb&Seq: no amplification, no enzymes, and no […]
