15 02, 2017

Nanostring Hyb&Seq

By | February 15th, 2017|Categories: Conferences, Methods and applications, Next-generation sequencing, Other stuff|Tags: , , |4 Comments

Nanostring had an interesting poster presented by Joe Beecham at last years AGBT describing their novel single-molecule hybridization-based sequencing chemistry (see AGBT and JPMorgan 2016 coverage from GenomeWeb). This utilizes the Nanostring optical barcodes in a new configuration to deliver Hyb&Seq: no amplification, no enzymes, and no […]

10 02, 2017

Finding a service provider on Genohub…”quality guaranteed”

By | February 10th, 2017|Categories: Commissioned content, Next-generation sequencing, Other stuff|0 Comments

This article was commissioned by Genohub. If you are looking for someone to run a next-generation sequencing project for you then hopefully many of the readers of the CoreGenomics blog will have seen the googlemap of NGS instruments (watch Enseqlopedia.com/NGS-mapped for a major refresh coming soon). However the […]

5 01, 2017

My predictions for Illumina’s JP Morgan announcments

By | January 5th, 2017|Categories: Next-generation sequencing, Other stuff|4 Comments

I thought I’d follow Keith’s lead and make my own suggestions for what might be revealed during Illumina’s presentation at this years JPMorgan event. All the great announcements, by Illumina and everyone else, used to be made at the AGBT meeting in February and that gave […]

21 12, 2016

Problems for breast cancer researchers in 2017?

By | December 21st, 2016|Categories: "Experimental design controls etc", Other stuff|1 Comment

Breast cancer researchers publish a lot of papers, and a large number of those will include some genomics, variant identification, RNA-Seq, ChIP-Seq, etc. Increasingly research is being carried out on patient derived material, but cell lines are still a vital part of much of the […]

5 09, 2016

Nuclear sharks live for 400 years

By | September 5th, 2016|Categories: Other stuff|0 Comments

A wonderful paper in a recent edition of Science uses radiocarbon dating to show that the Greenland shark can live for up to 400 years – making it the longest lived vertebrate known. See: Eye lens radiocarbon reveals centuries of longevity in the Greenland shark (Somniosus […]

2 09, 2016

Sequencing base modifications: going beyond mC and 5hmC

By | September 2nd, 2016|Categories: Other stuff|5 Comments

A great new resource was recently brought to my attention on Twitter and there is a paper describing it on the BioRxiv: DNAmod: the DNA modification database. Nearly all of the modified nucleotide sequencing we hear and read about is modifications to Cytosine mostly methyl cytosine […]

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