I asked ChatGPT this question one evening and working through the session was fun. Maybe it needs more fact-checking…I know some of my readers are fastidious enough to call me out if I’m wrong but here goes. When I started in Genomics it was still […]
This is a fantastic and comprehensive review on Cell-free DNA fragmentomics in cancer. Out in Cancer Cell by Denis Lo et al. In this review focused on cell-free DNA (cfDNA) fragmentomics in the context of cancer diagnostics the authors explore how analyzing cfDNA fragmentation patterns can provide […]
I’m really pleased to say I’m an author on a new article in Nature Cancer discussing the potential of using urine-based liquid biopsies for cancer detection, particularly through the analysis of circulating-cell-free-tumor DNA in urine (utDNA, cufDNA or ucpDNA). While urine offers advantages because it […]
The journey for an oncology patient often involves a relentless cycle of clinic visits, treatments, and crucially to the work I am involved with, blood draws for diagnosis, monitoring and MRD. This routine, while essential, presents significant burdens – from travel and time off work […]
And Fred said, let there be sequence: and there were sequencers.
Is Roche going to “knock it out of the park” or “jump the shark”? Everyone I know is excited, even if many of them are sceptical, about the Feb 20th webinar and what we will learn about SBX. Alex Dickinson appears to be driving most of the buzz, […]
A new study introduces a sensitive and cost-effective method for MCED and diagnostic using multimodal cfTAPS, enhancing the potential of liquid biopsies. In this post I’ll take a dive into the new paper, lay out a short overview of DNAme-mod methods development, and the possible […]
What does UK Biobank’s Pharma Proteomics election of Olink + Ultima Genomics NGS mean for proteomics researchers, and for the wider genomics community? Does it create a new Olink monopoly on NGS-proteommics? And what’s the impact on NGS technology providers? At the end of last […]
A new company, Tagomics, have a very interesting pre-print: Epigenomic profiling of active regulatory elements by enrichment of unmodified CpG dinucleotides that describes their novel epigenomic profiling approach called “Active-Seq”, a bisulfite-free method designed to enrich unmethylated DNA as opposed to enriching methylated (e.g. MeDIP, GH) or everything […]
NGS would not exist without the important discussions at The Panton Arms where Illumina Next-Generation sequencing was invented…sort of. Professors Sir David Klenerman and Sir Shankar Balasubramanian are being honoured with the 2024 Novo Nordisk Prize for their pioneering work on Solexa sequencing. This led to the $1000 […]
