Other than listing publications at the side of this blog, I would not normally cover in detail the work that my lab has contributed to or collaborated on. But there are two recent special cases, one just published (covered below) and another coming in five […]
I used to ride a BMWR1200RT on my daily commute from Wymondham to Cambridge. What I really wanted was an R1200GS like Ewan and Charlie rode around the world on during their easterly 19,000-mile London to New York trip through Europe and Asia to Alaska […]
I had a very interesting discussion over coffee yesterday at TRON, a new Translational Oncology institute in Mainz, Germany. TRON is specialising in cancer immunology and genomics, or Immunomics. One of the things they are aiming to do is develop personalised cancer vaccines by finding […]
I wrote this post after a recent experimental design discussion where we went round and round discussing RNA analysis.There are many different RNA molecules in a cell. When I was studying there were only three, mRNA, ribosomal RNA and tRNA. Simple! However over the last […]
I have previously blogged about amplicon sequencing (here, here and here) because I think it is one of the most exciting developments for clinical application of next-generation sequencing. Anyone can access the technology but there is a lot of choice about which system to use […]
This year I will be running a half-marathon and aiming to raise £2000 for Cancer Research UK. This is enough to sequence a Cancer genome which many of you will know is something we are doing in my lab. CRUK spent £332M in 2011 on […]
Illumina and Affymetrix both recently released Exome microarrays. The “death” of Gene expression microarrays: This is an interesting development considering there has been a lot of debate over the “death of arrays†in the last year or so. It does looks like 3’ expression arrays […]
One of the highlights at AGBT for me was Illumina’s announcement of a 687bp “perfect” read at AGBT on MiSeq. This was the longest read in a PE400bp dataset, the read had a 113bp overlap sequence where both ends gave the same basecalls. My first […]
AGBT is over and what a meeting it was. I have never been to a conference where it felt like everyone, and it really did feel like everyone was talking about the same thing over lunch. Oxford Nanopore made a big impact.There has been some […]
Rick Myers, HudsonAlpha Institute. Genetics and Epigenetics of Human Gene Regulation: Eukaryotic genome architecture is complex, cis and trans components looks like 1800 DNA binding proteins (what do they all do, can we find out before 2020). Talked about the promoter expansion in EPM1 gene […]
