10 01, 2022

@SingularGenomic is coming to a core facility near you in 2022

By | January 10th, 2022|Categories: Core facilities, Next-generation sequencing|Tags: , , |0 Comments

The new G4 benchtop sequencer from Singular Genomics is here. Sept 17th 2021 saw the first picture of the G4 in the wild from Beth Israel Deaconess Medical Center (see below). For anyone still recovering from a 2021 New Year’s hangover, the G4 is a […]

9 12, 2021

The best 2021 reviews of #MRD for solid tumours

By | December 9th, 2021|Categories: MRD|0 Comments

I thought I’d share my roundup of recent reviews that highlight the opportunities, challenges and current state-of-the-art in MRD analysis for solid tumours…enjoy! Moding 2021 (Cancer Discov.): Detecting Liquid Remnants of Solid Tumors: Circulating Tumor DNA Minimal Residual Disease a review from Ash Alizadeh and Max […]

21 01, 2021

@PacBio new management team knows a thing or two about sequencing ;-)

By | January 21st, 2021|Categories: Next-generation sequencing, Other stuff|0 Comments

I missed the announcement last Summer on Christian Henry’s move to PacBio as their new President & CEO, taking over from Mike Hunkapiller who recently retired – these are some big boots to fill! Christian was was previously Illumina EVP and CFO, having held the CFO […]

25 09, 2020

What is Minimal Residual Disease (MRD)?

By | September 25th, 2020|Categories: Early detection, Epigenomics, MRD, Next-generation sequencing|0 Comments

Many of my followers in the cancer space, especially the Hemes folks, will already understand what MRD is and why it’s important. But for those of you who don’t know I thought an explainer might be helpful. I took inspiration from Keiths COVID qPCR explainer and this […]

21 09, 2020

COVID diagnostics from @DNAnudge

By | September 21st, 2020|Categories: Diagnostics Tech, Methods and applications|0 Comments

A recent paper in The Lancet Microbe reports the first data from CovidNudge: DnaNudge’s rapid, lab-free COVID-19 test. The test: DnaNudge uses a SNP-genotyping technology developed by The Technology Partnership in Cambridge and explained in US10093965B2 patent. A sample is introduced into the Nudge cartridge, a disposable, sealed, and integrated lab-on-chip device,  […]

21 09, 2020

@illumina buys @GrailBio for $8 billion

By | September 21st, 2020|Categories: Diagnostics Tech, Early detection, Next-generation sequencing|1 Comment

Wow Illumina just spent $8 billion buying GRAIL; arguably the leader in methylation-based early detection of cancer with their Galleri test (read the press release). Get more info over at the website they’ve put together for the deal at transformingcancerdetection.com, which includes a presentation that also highlights […]

10 09, 2020

@10xGenomics buys @CARTANAbio for in situ GX analysis validation

By | September 10th, 2020|Categories: 10X Genomics, Methods and applications, Next-generation sequencing, Single-cell sequencing|0 Comments

CARTANA in situ sequencing was just bought by 10X Genomics for $41.2 million. They provide a complement to the Visium technology that generates beautiful gene expression maps of tissue sections as seen in Fig 1c of a recent bioRxiv report (see below). The method was […]

4 08, 2020

UK COVID diagnostics from @nanopore and @DNANudge

By | August 4th, 2020|Categories: Diagnostics Tech, Methods and applications, Nanopore sequencing, Next-generation sequencing|0 Comments

The UK biotech sector was in the news yesterday morning with two companies and their COVID tests making headlines: Oxford Nanopore and DNANudge. Both are offering rapid testing for COVID-19 in the NHS and in care homes (where they are desperately needed). There is only […]

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