11 04, 2016

WGS versus Exome: what’s best for cancer?

By | April 11th, 2016|Categories: Uncategorized|1 Comment

I’ve just started using Twitter polls and kicked things off with a couple asking followers whether they thought Cancer research (or diagnostics) is best investigated using whole genome sequencing, higher depth exomes, much higher depth amplicomes, or even long-reads. Please do take the poll and […]

17 03, 2016

How much is a 2nd hand HiSeq?

By | March 17th, 2016|Categories: Uncategorized|5 Comments

We recently bought two HiSeq 4000 instruments to run larger RNA-seq and exome projects on. Over the next few months we’ll be transitioning other library types where we can, and think perhaps 65-85% of the work we do can be ported over from the 2500. […]

7 03, 2016

A personal journey in Genomics

By | March 7th, 2016|Categories: Uncategorized|1 Comment

Eric Minikel is lead author on a paper that came out in STM in January: Quantifying prion disease penetrance using large population control cohorts. The story is an incredibly personal one involving his wife Sonia, which Eric documents at the cureFFI.org blog. The paper reports […]

13 02, 2016

AGBT16 it’s the final countdown!

By | February 13th, 2016|Categories: Uncategorized|2 Comments

Saturday, February 13, 2016 14:45Def Leppard are playing “Pour some sugar on me” while we wait for Nick Loman to walk on stage – not sure if this was intentional.Nick Loman, University of Birmingham “Real-time genome sequencing in the fieldâ€. Four years since Clive’s 2012 […]

13 02, 2016

AGBT16 day 4: KAPA HyperDrive

By | February 13th, 2016|Categories: Uncategorized|1 Comment

Saturday, February 13, 2016 12:12:Ross Wadsworth, KAPA Biosystems “Hyper Drive: high performance, streamlined workflows for RNA-seq and target enrichmentâ€. KAPA Hyper (Covaris frag, fast efficient library prep), KAPA Hyper+ (enzymatic frag, fast efficient library prep), now RNA is getting the Kapa touch!The RNA-seq workflow: mRNA […]

13 02, 2016

AGBT16 day 4: a new sequencing chemistry from Nanostring

By | February 13th, 2016|Categories: Uncategorized|0 Comments

Saturday, February 13, 2016 11:47:Joe Beecham Nanostring “New optical barcode chemistry’s power 3D biology & sequencing-simultaneous DNA, RNA, & protein analysis and low error-rate targeted sequencing†A sequencing system with no library prep or amplification – this is a pretty cool project. Joe is presenting […]

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